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通过己内酯(CL)和甲基丙烯酸二甲氨基乙酯(DMAEMA)的杂化聚合制备了主链含酯键结构单元的聚甲基丙烯酸二甲氨基乙酯的共聚物,并通过核磁(~1H-NMR)、凝胶渗透色谱(GPC)、示差扫描量热仪(DSC)等对聚合物的结构和性能进行了表征.结果表明,膦腈碱t-Bu P4能高效催化CL和DMAEMA的杂化聚合,得到含CL和DMAEMA 2种结构单元的刺激响应性可降解共聚物.该共聚物只存在一个玻璃化转变温度且共聚物组成与单体投料比接近.GPC数据表明共聚物的数均分子量范围为1.63×10~4~2.47×10~4,分子量分布为2.11~2.54.酯键的引入赋予了聚合物良好的降解性能,同时使其低临界相转变温度(LCST)从52.6℃降到了44.5℃.TEM结果表明得到的共聚物能够在水中形成平均直径约60 nm的胶束.
A copolymer of poly (N-methylaminoethyl methacrylate) whose main chain contains ester bond units was prepared by hybrid polymerization of caprolactone (CL) and dimethylaminoethylmethacrylate (DMAEMA) ~ 1H-NMR), gel permeation chromatography (GPC), differential scanning calorimetry (DSC), etc. The results show that the phosphonitrile base t-Bu P4 can efficiently catalyze CL and DMAEMA To obtain a stimuli-responsive biodegradable copolymer containing two structural units, CL and DMAEMA, which has only one glass transition temperature and a similar copolymer composition to monomer charge ratio. The GPC data show that the copolymer The number average molecular weight ranged from 1.63 × 10 ~ 4 ~ 2.47 × 10 ~ 4, and the molecular weight distribution ranged from 2.11 ~ 2.54. The introduction of ester bonds gave good degradation properties of the polymers with low LCST ranging from 52.6 ° C down to 44.5 ° C. TEM results show that the resulting copolymers are capable of forming micelles with an average diameter of about 60 nm in water.