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目的观察参附注射液对家兔缺氧型心脏骤停-心肺复苏(CA-CPR)模型循环恢复的影响。方法30只家兔随机分为三组,每组10只;夹闭气管复制缺氧型CA-CPR模型。预防组(A组)夹管前10min、自主循环恢复后8、15min分别静注参附注射液,治疗组(B组)自主循环恢复后8、15、22min静注参附注射液,对照组(C组)静注生理盐水,时间同A组;监测夹管前后家兔的心电图、平均动脉压(PAP)的变化,并记录开始CPR至自主循环恢复时间和自主呼吸恢复时间、肾上腺素用量、撤呼吸机时间;自主循环维持4h,并计算4h存活率。结果三组CPR成功率、4h存活率相近;在自主循环恢复时间方面A组明显快于C组,在自主呼吸维持时间、肾上腺素用量、撤呼吸机时间方面则两组相近。结论参附注射液可明显缩短家兔缺氧型CA-CPR模型的自主循环恢复时间,对促进CA的循环恢复具有积极意义。
Objective To observe the effect of Shenfu injection on cyclic recovery of rabbit model of hypoxic cardiac arrest-cardiopulmonary resuscitation (CA-CPR). Methods Thirty rabbits were randomly divided into three groups with 10 in each group. Clipped trachea was used to replicate the hypoxic CA-CPR model. In the prevention group (group A), Shenfu injection was intravenously injected 10 minutes before pinching and 8 and 15 minutes after the recovery of spontaneous circulation. The treatment group (group B) was intravenously injected with Shenfu injection at 8, 15, and 22 minutes after the recovery of spontaneous circulation. (Group C) intravenous saline, the same time as the A group; monitor ECG and mean arterial pressure (PAP) changes before and after pinching, and record the time from the start of CPR to spontaneous circulation recovery and spontaneous breathing recovery, adrenaline dosage Ventilator withdrawal time; autonomous circulation maintained for 4h, and 4h survival rate was calculated. Results The success rate of the three groups of CPR and the survival rate at 4 hours were similar. In group A, the recovery time of spontaneous circulation was significantly faster than that of group C. The two groups were similar in the duration of spontaneous breathing, adrenaline dosage, and ventilator withdrawal time. Conclusion Shenfu injection can significantly shorten the spontaneous circulation recovery time of rabbit model of hypoxic CA-CPR, and has positive significance for promoting the recovery of CA.