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目的:探讨骨感染患者并发菌血症的高危因素。方法:采用病例对照研究设计,共收集87例骨感染并发菌血症患者和298例仅仅骨感染患者的资料。采用自制问卷调查一般人口学情况、吸烟史、饮酒史及健康相关疾病情况等信息,并采集患者静脉血和骨组织检测细菌种类判断是否发生菌血症和骨感染情况。采用Kruskal-Wallis检验方法和逐步多因素Logistic回归模型筛选出骨感染并发菌血症患者的高危因素。结果与结论:骨感染细菌种类为金黄色葡萄球菌的患者、骨髓炎患者、在抗生素治疗之前有发热的患者及骨感染并有免疫抑制类疾病患者更易发生全身的菌血症。临床医生应该尽早识别骨感染高危患者,减少菌血症的发生。
Objective: To explore the risk factors of bacteremia in patients with bone infection. Methods: A case-control study was designed. A total of 87 patients with bone infection complicated by bacteremia and 298 patients with bone-only infection were collected. Self-made questionnaires were used to investigate general demographic information, smoking history, alcohol drinking history and health-related diseases. Venous blood and bone samples were collected from patients to determine whether there was bacteremia and bone infection. Kruskal-Wallis test and stepwise multivariate logistic regression model were used to screen the risk factors of patients with bone marrow infection complicated with bacteremia. RESULTS AND CONCLUSION: Patients with bone-infected bacterial species Staphylococcus aureus, osteomyelitis, patients with fever before antibiotic treatment and patients with bone infection and immunosuppressive diseases were more likely to develop systemic bacteremia. Clinicians should identify early high-risk patients with bone infections and reduce the incidence of bacteremia.