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目的 探讨内源性一氧化氮 (NO)与食管癌、贲门癌的关系。方法 应用硝酸还原酶法测定 5 0例食管癌、贲门癌患者血清、癌组织、癌旁组织中NO的生成量。结果 恶性肿瘤患者血清NO水平显著低于正常对照组 ,术后NO的恢复存在个体间差异 ,总体上与术前相比差异无显著性 ;癌旁组织匀浆NO含量高于癌组织NO含量 ,在癌侵及肌层时更为明显 ,侵及全层及外侵后 ,则两者间未见差异。结论 恶性肿瘤患者的免疫抑制是肿瘤源性的。NO水平变化为如何改善肿瘤病人全身、局部免疫抑制状态提供了有益的免疫学依据。
Objective To investigate the relationship between endogenous nitric oxide (NO) and esophageal cancer and cardiac cancer. Methods The nitric acid reductase method was used to determine the NO production in serum, cancer tissue and paracancer tissues of 50 patients with esophageal and cardiac cancer. Results The serum NO level in patients with malignant tumor was significantly lower than that in the normal control group. There was an inter-individual difference in the recovery of NO after operation. Overall, there was no significant difference between the two groups. The NO content in peritumoral tissue homogenate was higher than that in normal tissue, In cancer invasion and muscle layer more obvious invasion and full invasion, no difference between the two. Conclusion Immunosuppression in patients with malignant tumors is tumor-derived. The change of NO level provides a useful immunological basis for how to improve the systemic and local immunosuppressive status of tumor patients.