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目的：研究联合应用肿瘤坏死因子（TNF）、干扰素－γ（IFN－γ）和更生霉素（KSM）对人卵巢癌裸鼠模型的协同作用。方法：将荷瘤裸鼠随机分成4组，分别用生理盐水、KSM、TNF＋IFN－γ、KSM＋TNF＋IFN－γ处理，观察肿瘤生长情况。结果：各组肿瘤相对体积比较，KSM组和KSM＋TNF＋IFN－γ组与对照组比较，差异有显著性（P＜0．05和P＜0．01）；TNF＋IFN－γ组与对照组比较，差异无显著性（P＞0．05），而KSM＋TNF＋IFN－γ组与KSM组比较，差异有显著性（P＜0．05）。结论：KSM与TNF、IFN－γ联合应用有协同抗卵巢癌细胞系3AO的作用，为临床应用提供了理论依据。
Objective: To investigate the synergistic effect of combined application of tumor necrosis factor (TNF), interferon-γ (IFN-γ) and dactinomycin (KSM) on human ovarian cancer in nude mice model. Methods: Tumor bearing nude mice were randomly divided into 4 groups, treated with normal saline, KSM, TNF + IFN-γ, KSM + TNF + IFN-γ, respectively. Results: Compared with the control group, the relative volume of tumors in each group was significantly different (P <0.05 and P <0.01). There was no significant difference between the control group and the KSM + TNF + IFN-γ group (P> 0.05). However, there was significant difference between KSM + TNF + IFN-γ group and KSM group (P <0.05). Conclusion: The combination of KSM with TNF and IFN-γ has the synergistic effect on anti-ovarian cancer cell line 3AO, which provides a theoretical basis for clinical application.