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目的综述近年来基因多态性分析在指导器官移植受体免疫抑制剂的个体化治疗方面的最新研究进展。方法通过调研近年来国内外文献,较全面地介绍遗传基因多态性在影响免疫抑制剂吸收和分布等方面的研究现状及发展趋势。结果与结论目前已经明确的能影响免疫抑制剂吸收和分布的主要有巯基嘌呤甲基转移酶(TPMT)和细胞色素P450 3A5,而未来需要进一步明确的是与药物作用靶点有关的等位基因变异问题,并将基因多态性及药动学等参数综合考虑,建立数学模型,以期提供个体化的最佳的免疫抑制剂治疗方案。
OBJECTIVE: To summarize the recent progress of gene polymorphism analysis in the individualized treatment of organ transplant recipients immunosuppressive agents in recent years. Methods By investigating the literature at home and abroad in recent years, the status quo and development trend of genetic polymorphisms in the absorption and distribution of immunosuppressive agents were introduced. RESULTS AND CONCLUSION Currently, there are mainly mercaptopurine methyltransferase (TPMT) and cytochrome P450 3A5, which can affect the absorption and distribution of immunosuppressive agents. However, in the future, it is necessary to further clarify the alleles related to drug targets Mutation and gene polymorphism and pharmacokinetic parameters considered, the establishment of mathematical models, with a view to providing individualized best immunosuppressive treatment program.