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Domagk于1947年报告氨基硫脲类化合物具抗结核菌性能,并进而找出对-乙酰氨基苯甲醛缩氨基硫脲(p-Acetylaminobenzaldehyde thiosemicarbazone)有强大的抗结核菌效用。其后如TBⅢ等化合物的合成和介绍亦陆续见于文献中。本文由对-氯磺酰基苯甲醛二乙酯(p-chlorosulfonylbenzaldehyde diacetate)与异菸酰肼于吡啶溶液中作用,合成对-异菸酰肼磺酰基-苯甲醛二乙酯(p-isonicotinyl
Domagk reported in 1947 that thiosemicarbazones have anti-tuberculotic properties and therefore found a potent anti-tuberculosis effect on p-Acetylaminobenzaldehyde thiosemicarbazone. Subsequent, such as TB Ⅲ synthesis and introduction of other compounds are also found in the literature. In this paper, p-isonicotinhydrazosulfonyl-benzaldehyde diethyl ester (p-isonicotinyl) was synthesized by the reaction of p-chlorosulfonylbenzaldehyde diacetate and isonicotinic acid hydrazide in pyridine solution.