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为了探讨婴幼儿哮喘的防治方法并了解其预后，从１９９０～１９９５年，我们对陆续收治的３３０例婴幼儿哮喘随机单盲分为５组。Ａ组：６３例应用必可酮气雾剂与酮替芬防治：Ｂ组：６６例应用脱敏治疗口服酮替芬防治：Ｃ组：６７例应用必可酮气雾剂，脱敏治疗及口服酮替芬防治；Ｄ组：６７例仅口服酮替芬和氨茶硷防治：Ｅ组（对照组）：６７例仅于急性发作期治疗。防治组总疗程至少一年，平均随访２～３年，结果发明：Ａ、Ｂ．Ｃ组有效率高达８０．１％（５１／６３），８４．４％（５６／６６），９２．５％（６２／６８），令人满意。Ｄ组、Ｅ组有效率分别为５６．１％（３７／６６）与２６．５％（１８／６８），提示预后不良。作者建议对婴幼儿哮喘应采用早期、正规、长程联合防治。
In order to explore the method of prevention and treatment of asthma in infants and young children and its prognosis, from 1990 to 1995, we randomly divided 330 infants and young children with asthma randomly into five groups. Group A: 63 patients were treated with ketoconazole and ketotifen. Group B: 66 patients were treated with desensitization oral ketotifen. Group C: 67 patients were treated with ketoconazole-based aerosol, desensitization and Oral ketotifen prevention and treatment; D group: 67 cases of oral ketotifen and ammonia theophylline control: E group (control group): 67 cases only acute exacerbation treatment. Control group total course of at least one year, with an average follow-up of 2 to 3 years, the results found: A, B. C group was as effective as 80.1% (51/63), 84.4% (56/66), 92.5% (62/68), satisfactory. The effective rates of group D and group E were 56.1% (37/66) and 26.5% (18/68) respectively, which suggested that the prognosis was poor. The authors suggest that early childhood, regular, long-term joint prevention and treatment should be adopted.