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目的探讨医用射线防护剂防治鼻咽癌调强放疗患者放射性皮炎的效果。方法方法选取66例鼻咽癌且接受调强放疗的患者为研究对象,随机分为对照组和观察组,每组33例。对照组采用常规皮肤防护护理,观察组在常规护理基础上从放疗第一天开始使用射线防护剂,每天4次,分别为放疗前1小时、放疗后1小时及早晚前各一次,从放疗开始直到放疗结束。比较两组患者照射野放射性皮炎程度及发生时间。结果两组患者皮肤损伤的发生率均为100%。但观察组皮肤损伤的程度明显低于对照组(P<0.05)。对照组和观察组皮肤放射性损伤出现时间分别为(30.2±1.7)d、(35.1±1.5)d,组间比较差异显著(P<0.05)。结论采用医用射线防护剂可明显降低鼻咽癌调强放疗患者放射性皮炎程度,延迟放射性皮炎发生时间。
Objective To investigate the effect of medical radioprotective agent on radiodermatitis in patients with nasopharyngeal carcinoma treated by intensity modulated radiotherapy. Methods Sixty-six patients with nasopharyngeal carcinoma who received IMRT were randomly divided into control group and observation group, with 33 cases in each group. The control group received routine skin protection and nursing care. On the basis of routine nursing, the observation group started to use radioprotectants 4 times a day from the first day of radiotherapy, one hour before radiotherapy, one hour after radiotherapy and one night before radiotherapy. From the start of radiotherapy Until the end of radiotherapy. Radiation dermatitis level and time were compared between the two groups. Results The incidence of skin lesions in both groups was 100%. However, the degree of skin damage in the observation group was significantly lower than that in the control group (P <0.05). The appearance time of skin radiological damage in the control group and observation group were (30.2 ± 1.7) days and (35.1 ± 1.5) days, respectively. There was significant difference between the two groups (P <0.05). Conclusion The use of medical radioprotective agents can significantly reduce radiation dermatitis in patients with radiation-modulated radiation therapy of nasopharyngeal carcinoma and delay the onset time of radiodermatitis.