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巴豆属植物 Croton cajucara 在巴西民间用于治疗多种疾病。作者从其树皮中分离出二萜成分 trans-dehydrocrotonin(t-DCTN),并通过腹腔注射和管饲法给以诱变剂环磷酰胺,研究 t-DCTN 的抗基因毒活性。
Croton cajucara is used in Brazilian folk for the treatment of many diseases. The authors isolated the diterpene trans-dehydrocrotonin (t-DCTN) from its bark, and administered the mutagens cyclophosphamide via intraperitoneal injection and gavage to study the anti-genomic activity of t-DCTN.