目的 了解新生儿全身炎症反应综合征(SIRS)及多器管功能不全综合征 (MODS)的预后及影响因素。方法 回顾性地分析我院新生儿重症监护病房 (NICU) ,于1997年1月～1999年12月收治的危重新生儿。结果 全组252例新生儿 ,符合SIRS诊断标准161例 ,占64%。最终发展为MODS84例 ,占52 % ,死亡32例 ,病死率为38.1 %。产伤、窒息、患儿成熟度及胎粪羊水污染易发展为MODS ,死亡率明显高于非MODS组。结论 SIRS和MODS在NICU中发生率和病死率均高 ,而围产因素严重影响其预后。必须早期干预 Objective To investigate the prognosis and influential factors of neonatal systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). Methods A retrospective analysis of our hospital neonatal intensive care unit (NICU), from January 1997 to December 1999 admitted critically ill newborns. Results The whole group of 252 newborns, in line with SIRS diagnostic criteria 161 cases, accounting for 64%. The final development of MODS 84 cases, accounting for 52%, 32 deaths, the case fatality rate was 38.1%. Birth injury, asphyxia, children’s maturity and meconium amniotic fluid contamination easily developed into MODS, the mortality rate was significantly higher than non-MODS group. Conclusions Both incidence and mortality of SIRS and MODS in NICU are high, and perinatal factors seriously affect their prognosis. Must be early intervention