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目的探讨细胞间黏附分子-1(intercellular adhesion molecule-1,ICAM-1)和冠状动脉慢血流(coronary slow flow,CSF)的相关性。方法因胸痛行冠状动脉造影且未发现明显病变者186例,根据校正的TIMI帧数(correlated TIMI frame count,CTFC)法分为CSF组78例及对照组108例。比较2组一般资料;采用ELISA测定患者血浆ICAM-1水平,分析CSF的危险因素。结果 CSF组血浆ICAM-1[(336.3±75.6)μg/L]高于对照组[(294.4±65.5)μg/L](P<0.05),2组年龄、性别,合并高血压、高脂血症比率比较差异均无统计学意义(P>0.05);多因素logistic回归分析显示,在调整其他心血管危险因素影响后,ICAM-1水平升高(OR=3.449,95%CI:1.687~9.234,P=0.000)是发生SCF的独立危险因素。结论 ICAM-1在CSF发生中有重要作用,其水平升高可能是CSF发生的危险因素之一。
Objective To investigate the correlation between intercellular adhesion molecule-1 (ICAM-1) and coronary slow flow (CSF). Methods One hundred and sixty-six patients with chest pain underwent coronary angiography and no obvious pathological changes were divided into CSF group (78 cases) and control group (108 cases) according to the corrected TIMI frame count (CTFC). The general data of two groups were compared. The levels of ICAM-1 in plasma were measured by ELISA, and the risk factors of CSF were analyzed. Results The ICAM-1 level of CSF in the CSF group was significantly higher than that in the control group [(294.4 ± 65.5) μg / L vs (336.3 ± 75.6) μg / L, P <0.05) (P> 0.05). Multivariate logistic regression analysis showed that the level of ICAM-1 was increased after adjusting for other cardiovascular risk factors (OR = 3.449, 95% CI: 1.687-9.234 , P = 0.000) was an independent risk factor for developing SCF. Conclusion ICAM-1 plays an important role in the pathogenesis of CSF. Elevated levels of ICAM-1 may be one of the risk factors of CSF development.