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目的:探讨自然人群中超敏C-反应蛋白(hsCRP)与代谢综合征的关系。方法:在江苏省高邮市送桥镇随机入选609名18～74岁农村居民,使用标准流行病学调查表进行问卷调查,并测量血压,空腹抽血常规生化检查,免疫比浊法测量hsCRP。根据2004年国际糖尿病联盟(IDF)推荐的有关中国人代谢综合征(MS)的诊断标准诊断。结果:随着代谢综合征组分的聚集,男性与女性的hsCRP均有显著升高(校正后男性P=0.043,女性P=0.003)。校正年龄、吸烟史、饮酒史、服药史及心率后,logistic回归提示男性与女性hsCRP均与代谢综合征患病率独立相关(男性P=0.002,女性P=0.001),总人群进一步调整性别后,关系仍显著(P<0.0 1)。校正类似的变量后,偏相关分析显示,在总人群及各性别亚组中,腰围和甘油三酯均与hsCRP相关,而收缩压及高密度脂蛋白胆固醇仅在总人群及男性组中与hsCRP相关。结论:hsCRP与代谢综合征各组分及其患病风险独立相关。
Objective: To investigate the relationship between hsCRP and metabolic syndrome in the natural population. Methods: 609 rural residents aged 18-74 years old were selected randomly from Songqiao Town of Gaoyou City, Jiangsu Province. Questionnaires were conducted using standard epidemiological questionnaires. Blood pressure, fasting blood biochemical tests and immune turbidimetric method were used to measure hsCRP. According to 2004 International Diabetes Federation (IDF) recommended diagnosis of Chinese people’s metabolic syndrome (MS) diagnostic criteria. Results: With the aggregation of metabolic syndrome components, hsCRP was significantly increased in both males and females (adjusted P = 0.043 for males and P = 0.003 for females). After adjusting for age, smoking history, drinking history, medication history and heart rate, logistic regression suggested that both male and female hsCRP were independently associated with the prevalence of metabolic syndrome (male P = 0.002, female P = 0.001) , The relationship is still significant (P <0.0 1). After adjusting for similar variables, partial correlation analysis showed that waist circumference and triglycerides were both associated with hsCRP in the general population and in all sex subgroups, whereas systolic and HDL cholesterol were only associated with hsCRP Related. Conclusion: hsCRP is independent of the components of the metabolic syndrome and its risk.