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目的:探讨视黄醇结合蛋白(RBP)在肾脏疾患中的临床应用,并比较其与β2-微球蛋白、尿素氮、肌酐几项化验指标之间的敏感性和实用性。方法:选取51例肾脏疾病患者,分别检验RBP、BUN、Cr、β2-微球蛋白指标,对其阳性率结果进行比较。结果:RBP与β2-微球蛋白在肾脏疾患中阳性率无显著差异,P>0.05,RBP与BUN、Cr比较阳性率有显著差异,P<0.05。结论:BRP可做为早期发现肾功能损害的实验室指标,对监测肾功能变化,推测肾脏疾病的预后有重要意义。
Objective: To investigate the clinical application of retinol binding protein (RBP) in renal diseases and to compare its sensitivity and practicability with β2-microglobulin, urea nitrogen and creatinine. Methods: Fifty-one patients with kidney disease were selected to test the indexes of RBP, BUN, Cr and β2-microglobulin. The positive rates were compared. Results: The positive rates of RBP and β2-microglobulin in renal disease were not significantly different (P> 0.05). The positive rates of RBP and BUN and Cr were significantly different (P <0.05). Conclusion: BRP can be used as a laboratory index for early detection of renal dysfunction. It is of great significance to monitor the changes of renal function and speculate on the prognosis of renal diseases.