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Nephrin是近年来在肾小球足突裂孔膜发现的第一个跨膜糖蛋白 ,为粘附分子类的免疫球蛋白超家族成员 ,可能具有细胞间粘附作用、信号传导功能及促进足细胞与足突裂孔膜发育成熟的作用。在先天性与获得性肾病存在其基因异常或mRNA表达的变化及其分布位置的改变 ,结果使滤过膜形态结构与屏障功能完整性破坏 ,导致大量蛋白尿产生。Nephrin的发现为蛋白尿病理机制的研究提供了崭新的途径 ,为的基因治疗带来了希望。
Nephrin is the first transmembrane glycoprotein found in the glomerular foot process membrane in recent years. It is a member of the immunoglobulin superfamily of adhesion molecules that may have cell-cell adhesion, signal transduction and podocyte promotion And the development of podophytic cell membrane mature role. In congenital and acquired nephropathy, there is a change of its gene abnormality or mRNA expression and its distribution location. As a result, the integrity of the membrane structure and barrier function is destroyed, resulting in a large amount of proteinuria. The discovery of Nephrin provides a new way for the study of the pathogenesis of proteinuria and brings hope for gene therapy.