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目的观察牛黄熄风胶囊对经阿替普酶(rt-PA)静脉溶栓后的急性脑梗死疗效的影响,初步探讨其治疗急性脑梗死的不良反应。方法分析30例牛黄熄风胶囊治疗经rt-PA静脉溶栓后的急性脑梗死患者的临床资料,评价患者溶栓后24h,3个月后的临床疗效。根据美国国立卫生院卒中量表(NIHSS评分)及改良Rank量表(mRS评分)评价神经功能恢复情况及预后,同时通过观察安全性指标评价牛黄熄风胶囊对肝功、肾功的影响。结果治疗后神经功能缺损恢复良好者51例,不良者9例,两组治疗后组间NIHSS评分比较,差异具有显著性(P=0.00)。3个月后随访评价患者mRS评分改善情况,经比较两组治疗后差异具有显著性(P=0.00),同时肝肾功方面未见明显不良影响。结论牛黄熄风胶囊合理应用能改善急性脑梗死治疗的临床效果,并且未见远近期不良影响。
Objective To observe the effect of Niuhuang Xifeng Capsule on the curative effect of acute cerebral infarction after intravenous infusion of rt-PA and to discuss its adverse reaction in the treatment of acute cerebral infarction. Methods The clinical data of 30 cases of Begonia Xifeng Capsule in the treatment of acute cerebral infarction after rt-PA thrombolysis were analyzed, and the clinical curative effect after 24h and 3 months after thrombolysis was evaluated. Neurological recovery and prognosis were evaluated according to the National Institutes of Health Stroke Scale (NIHSS) and the modified Rank Scale (mRS), and the effects of Niuhuang Xifeng capsule on liver function and kidney function were evaluated by observing the safety index. Results After treatment, 51 cases of good neurological deficit recovery, 9 cases of poor, NIHSS scores between the two groups after treatment, the difference was significant (P = 0.00). After 3 months follow-up evaluation of mRS score improvement in patients after treatment, the difference was significant (P = 0.00), while liver and kidney function no significant adverse effects. Conclusion The rational application of bezoar Xifeng capsule can improve the clinical efficacy of acute cerebral infarction treatment, and no adverse effects in the near and far.