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1959年,Taylor、Sehwartz等在恶性贫血者体内发现了内因子抗体(IFA)以来,推断萎缩性胃炎在自体也有自家免疫机制,1962年Irvine、Taylor 等都发现了胃壁细胞抗体(PC-A-parietal cell antibody)之后,胃粘膜萎缩和本抗体之间的关系逐渐得以明瞭。1.内因子抗体(IFA)IFA 既在血清中也在胃液中被证实。IFA有两种,一种是VitB_(12)和内因子结合时阻碍和内因子相结合的抗体是Ⅰ型抗体,另一种是对抗内因子和B_(12)的复合体的抗体是Ⅱ型抗体。前者一般能检出,后者仅在前者浓度高的时候才被检出。其阳性率随方法而异,但在恶性贫
In 1959, Taylor, Sehwartz et al. discovered intrinsic factor antibody (IFA) in pernicious anemia, and concluded that atrophic gastritis also has its own immune mechanism in autologous. In 1962, Irvine and Taylor et al. discovered gastric parietal cell antibody (PC-A- After the parietal cell antibody, the relationship between gastric mucosal atrophy and this antibody gradually became clear. 1. Intrinsic factor antibody (IFA) IFA was confirmed both in serum and in gastric juice. There are two kinds of IFA, one is that when the combination of VitB_(12) and intrinsic factor blocks the binding of intrinsic factor, it is type I antibody, and the other is anti-integrin and B_(12). The antibody is type II. antibody. The former can generally be detected, the latter only when the former is at a high concentration. The positive rate varies depending on the method, but in the malignant