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血小板活化因子(PAF)是一种磷脂信号分子,主要通过细胞膜表面的PAF受体(PAF-R)———G蛋白耦联受体,将细胞内信号传导至多种类型的细胞效应器。PAF在多种有害刺激下与PAF-R结合并发生磷酸化,激活信号传导通路及细胞内第二信使,如环磷酸鸟苷、磷脂酰肌醇、磷脂酶C、磷酸肌酸激酶及钙离子等生物效应,并可介导转录因子如核因子(NF)-κB的活化,激发并扩大急性炎症和凝血反应等,从而介导参与多种疾病的病理过程。在脓毒症、休克、创伤中,PAF信号系统失调,中断效应器反应会引起好的结果。随着研究深入,发现PAF与新生儿疾病的发生、发展有密切关系。现就PAF的结构、代谢、功能及其与新生儿疾病的相关性进行综述。
Platelet-activating factor (PAF) is a phospholipid signaling molecule that directs intracellular signaling to many types of cellular effectors, primarily through the PAF receptor (PAF-R), a G protein-coupled receptor on the cell membrane surface. PAF binds to PAF-R and phosphorylates under various noxious stimuli, activating signaling pathways and intracellular second messengers such as guanosine monophosphate, phosphatidylinositol, phospholipase C, phosphocreatine kinase and calcium ions And other biological effects, and can mediate the activation of transcription factors such as nuclear factor (NF) -κB, stimulate and expand acute inflammation and clotting reactions, and thus to participate in a variety of diseases involved in the pathological process. In sepsis, shock, trauma, the PAF signaling system is disrupted, disrupting the effector response leads to good results. With further research, we found that PAF is closely related to the occurrence and development of neonatal diseases. Now on the PAF structure, metabolism, function and its relationship with neonatal disease are reviewed.