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目的:分析沙利度胺的不良反应(ADRs)和临床应用,为临床合理用药提供参考。方法:系统回顾国外有关沙利度胺的临床文献报道,并进行分析整理。结果:沙利度胺的不良反应涉及胃肠道反应、血液毒性、心血管毒性、神经毒性、皮肤损害、肺栓塞等。此外,其新的临床应用也较为广泛。结论:临床医师及药师应重视沙利度胺的用药风险与合理用药,以保障临床用药安全、有效。
Objective: To analyze the adverse reactions (ADRs) and clinical application of thalidomide, and to provide a reference for clinical rational drug use. Methods: The clinical reports of thalidomide abroad were systematically reviewed and analyzed. Results: Thalidomide adverse reactions involved gastrointestinal reactions, hematological toxicity, cardiovascular toxicity, neurotoxicity, skin lesions, pulmonary embolism and so on. In addition, its new clinical application is also more extensive. Conclusion: Clinicians and pharmacists should pay attention to the risk and rational use of thalidomide in order to ensure the safety and effectiveness of clinical medication.