继羊促肾上腺皮质激素释放因子(CRF)之后,1983年Rivier 等提出了大鼠CRF。应用放射免疫和免疫细胞化学技术,发现在大鼠中枢神经系统内CRF 有广泛的分布。最近美国Yasuda 等的实验表明,大鼠下丘脑外的CRF 不是来源于下丘脑,同时也和下丘脑CRF 有不同的分子型式。手术损毁整个下丘脑后8天,大脑皮层枕叶、额叶和颞叶(0.2～0.4ng/mg)、小脑(0.25ng/mg)和脊 Following the adrenocorticotropic hormone releasing factor (CRF), Rivier et al. Proposed a rat CRF in 1983. Using radioimmunoassay and immunocytochemistry, CRF was found to be widely distributed in the central nervous system of rats. Recent experiments by Yasuda et al. In the United States have shown that rat hypothalamic CRF is not derived from the hypothalamus and has a different molecular pattern than hypothalamic CRF. Eight days after surgery, the occipital lobe of the cerebral cortex, frontal and temporal lobes (0.2-0.4 ng / mg), cerebellum (0.25 ng / mg) and ridges