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分泌成分(SC)是腺上皮细胞和某些动物肝细胞的受体,它能调节IgA和IgM的多聚体(pIgA和pIgM)向分泌液的输送.SC-pIgA系统是一种独特的受体一配体反应形式.受体与配体结合后,既不再循环,也不被降解,而是与配体形成复合物后被细胞分泌.SC已引起免疫学家和细胞生物学家的浓厚兴趣.小肠和结肠腺上皮细胞、胰胆管上皮及某些情况下的胃上皮细胞能合成SC.最近发现某些动物的肝细胞也有SC表达,SC并与血清IgA进入胆汁的量有关.因此,SC对胃肠和肝脏病学者也是一种重要分子.SC参与粘膜和肝脏免疫80～95%血清IgA是7S的IgA单体.哺
Secretory component (SC), a receptor for glandular epithelial cells and hepatocytes in some animals, regulates the delivery of multimers (pIgA and pIgM) of IgA and IgM to secretions. The SC-pIgA system is a unique A ligand-reactive form. After the receptor binds to the ligand, it neither recycles nor degrades, but is secreted by the cell after forming a complex with the ligand.SC has caused immunological and cell biologists’ Interested in. Small intestine and colon glandular epithelium, pancreatic ductal epithelium and gastric epithelial cells in some cases can synthesize SC. Recently, some animals also found SC cells in the liver cells, SC and the amount of serum IgA into the bile. , SC is also an important molecule for gastrointestinal and liver disease scholars.SC is involved in mucosal and hepatic immunity 80-95% of serum IgA is 7S IgA monomer.