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目的:探讨丹红注射液联合氯吡格雷治疗不稳定性心绞痛(unstable angina pectoris,UAP)的临床疗效及对患者血脂和炎性因子的影响。方法:采用随机数字表法将于滨州市人民医院接受治疗的142例符合纳入标准的UAP患者分为对照组(n=72)和观察组(n=70)。在常规治疗的基础上,对照组给予氯吡格雷治疗,观察组在对照组治疗的基础上联合应用丹红注射液治疗。比较两组患者的临床疗效,总胆固醇(total cholesterol,TC),甘油三酯(triglyceride,TG),低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C),高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)水平,肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α),白细胞介素-1(interleukin-1,IL-1),白细胞介素-6(interleukin-6,IL-6)水平变化及不良反应发生情况。结果:观察组的治疗有效率为95.7%,明显高于对照组的总有效率84.7%(P<0.05),血瘀证型治疗总有效率高达92.9%,明显高于对照组的总有效率73.6%(P<0.05)。与对照组相比,观察组治疗后血脂指标TC[(4.60±0.24)VS(5.12±0.32)mmol·L-1],TG[(1.82±0.32)VS(2.41±0.27)mmol·L-1],LDL-C[(2.61±0.34)VS(3.36±0.33)mmol·L-1]水平显著降低,HDL-C[(1.71±0.22)VS(1.35±0.23)mmol·L-1]水平明显升高,炎性因子TNF-α[(54.21±9.57)VS(65.34±9.27)ng·L-1],IL-1[(0.28±0.09)VS(0.45±0.11)ng·L-1]和IL-6[(6.28±3.24)VS(9.55±3.64)ng·L-1]的水平显著降低,比较差异均有统计学意义(P<0.05)。治疗过程中,均未出现严重不良反应,观察组和对照组不良反应发生率分别为8.6%和11.1%,组间比较差异无统计学意义。结论:丹红注射液联合氯吡格雷是UAP的有效治疗方案,可以显著提高临床疗效和改善血脂水平,并减轻炎性反应,临床上值得进一步研究。
Objective: To investigate the clinical efficacy of Danhong injection combined with clopidogrel in the treatment of unstable angina pectoris (UAP) and its effect on serum lipids and inflammatory factors. Methods: A total of 142 eligible UAP patients treated in Binzhou People ’s Hospital were randomly divided into control group (n = 72) and observation group (n = 70). On the basis of routine treatment, the control group was treated with clopidogrel, and the observation group was treated with Danhong injection on the basis of the control group. The clinical efficacy, total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol lipoprotein cholesterol and HDL-C, the levels of tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), interleukin-6 , IL-6) levels and adverse reactions. Results: The effective rate of treatment in observation group was 95.7%, significantly higher than that in control group (84.7%, P <0.05), total effective rate of blood stasis syndrome was 92.9%, significantly higher than that in control group 73.6% (P <0.05). Compared with the control group, the TC of the observation group after treatment was significantly higher than that of the control group (TC [(4.60 ± 0.24) vs (5.12 ± 0.32) mmol·L-1], TG [1.82 ± 0.32 vs VS 2.41 ± 0.27 mmol·L-1 ], LDL-C [(2.61 ± 0.34) VS (3.36 ± 0.33) mmol·L-1], and the levels of HDL-C [(1.71 ± 0.22) VS (1.35 ± 0.23) mmol·L-1] IL-1 [(0.28 ± 0.09) VS (0.45 ± 0.11) ng · L-1] and inflammatory cytokines TNF-α (54.21 ± 9.57 vs 65.34 ± 9.27 ng · L -1) The level of IL-6 [(6.28 ± 3.24) VS (9.55 ± 3.64) ng · L-1] was significantly lower than that of control group (P <0.05). During the course of treatment, no serious adverse reactions occurred. The incidences of adverse reactions in the observation group and the control group were 8.6% and 11.1% respectively, with no significant difference between the two groups. Conclusion: Danhong injection combined with clopidogrel is an effective treatment for UAP, which can significantly improve the clinical efficacy and improve blood lipid levels, and reduce the inflammatory response, it is worth further study clinically.