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目的了解上海口岸入境人群中单纯疱疹病毒II型(HSV-2)感染率及其流行病学特征,为口岸性传播疾病的科学防控提供依据。方法随机抽取2012年5月上海口岸艾滋病病毒(HIV)、丙型肝炎病毒(HCV)和梅毒螺旋体抗体检测阴性的入境人员874名以及历年上述3种抗体检测任一阳性的入境人员167名,运用酶联免疫吸附试验(ELISA)检测血清中HSV-2特异性Ig G抗体,并利用SPSS软件对数据进行统计学分析。结果 874名HCV、HIV和梅毒抗体全阴性者中154例HSV-2抗体阳性,感染率17.6%,且随着年龄增长,HSV-2感染率随之增长(χ2=17.255,P<0.001)。HIV、HCV或梅毒螺旋体抗体检测任一阳性的167名入境人员中52例HSV-2抗体阳性,感染率31.1%,其中,女性感染率为45.5%,男性感染率为26.0%,女性显著高于男性(χ2=5.711,P=0.017)。结论上海口岸入境人员中HSV-2抗体阳性率较高,尤其伴随HCV、HIV、梅毒螺旋体感染时感染率高达31.1%,远高于我国普通及某些特殊人群的平均感染水平,因此,入境人员中较高的HSV-2感染率对HSV-2向我国传播扩散形成威胁和压力,应加强入境人员HSV-2血清学监测,严防通过口岸传播。
Objective To understand the prevalence and epidemiological characteristics of herpes simplex virus type 2 (HSV-2) in the entry population of Shanghai port and provide a basis for scientific prevention and control of sexually transmitted disease at port. Methods A total of 874 inbound immigrants from the Shanghai port of Shanghai, HIV, Hepatitis C virus (HCV) and Treponema pallidum in May 2012 and 167 immigrants who tested positive for any of the three antibodies over the previous year were enrolled in this study. Enzyme-linked immunosorbent assay (ELISA) detection of serum HSV-2-specific Ig G antibodies, and the use of SPSS software for statistical analysis. Results Among 874 HCV, HIV and syphilis antibodies, 154 cases were positive for HSV-2 antibody with a 17.6% infection rate. The incidence of HSV-2 infection increased with age (χ2 = 17.255, P <0.001). Among the 167 immigrants who tested positive for HIV, HCV or Treponema pallidum, 52 cases were positive for HSV-2 antibody, with a prevalence of 31.1%. Among them, the infection rate was 45.5% for women and 26.0% for men, which was significantly higher than that of women Male (χ2 = 5.711, P = 0.017). Conclusions The positive rate of HSV-2 antibody is high in immigrants from Shanghai Port, especially when infected with HCV, HIV and Treponema pallidum, which is as high as 31.1%, which is much higher than the average level of infection of common and some special populations in China. Therefore, The higher HSV-2 infection rate will threaten and pressure HSV-2 to spread and spread to our country. HSV-2 serological surveillance should be strengthened to prevent the spread of HSV-2 through ports.