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多发性骨髓瘤(multiple myeloma,MM)是一种血液系统的恶性肿瘤,其特征是单克隆浆细胞恶性增殖并分泌大量单克隆免疫球蛋白,属于单克隆免疫增殖性疾病。几乎所有的MM前期均有“前骨髓瘤”的过渡状态,其主要代表的是意义未明的单克隆免疫球蛋白血症(monoclonal gammopathy of undetermined significance,MGUS)和冒烟型多发性骨髓瘤(或无症状性多发性骨髓瘤)(smoldering/asymptomatic multiple myeloma,SMM)~([1-2])。从更广泛
Multiple myeloma (MM) is a hematological malignancy characterized by the malignant proliferation of monoclonal plasma cells and the secretion of large numbers of monoclonal immunoglobulins, which are monoclonal immunoproliferative diseases. Almost all of the early stages of MM have a transitional state of “anterior myeloma,” which mainly represents monoclonal gammopathy of undetermined significance (MGUS) of unknown significance and smoking-type multiple myeloma (Or asymptomatic multiple myeloma, SMM) ~ ([1-2]). From a wider range