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目的 :了解宫颈癌患者介入治疗前后血清可溶性白细胞介素 - 2受体 ( s IL- 2 R)的变化。方法 :采用双抗体夹心酶联免疫吸附试验 ( EL ISA法 )检测 30例宫颈癌患者在介入治疗前后血清 s IL- 2 R的水平 ,并与正常对照组比较。结果 :宫颈癌患者在介入治疗前血清 s IL - 2 R水平明显高于正常对照组 ( P <0 .0 0 1) ,且水平升高与病灶大小、临床分期呈正相关 ;治疗后患者血清 s IL- 2 R水平较治疗前明显降低 ( P <0 .0 0 1) ,但仍显著高于对照组 ( P <0 .0 5 )。结论 :宫颈癌患者血清 s IL- 2 R的变化与临床分期、癌灶的大小及消长呈正相关 ,在介入治疗前后检测患者血清 s IL - 2 R水平可能有助于病情判断和疗效的估计
Objective: To investigate the changes of serum soluble interleukin - 2 receptor (sIL - 2R) in patients with cervical cancer before and after interventional therapy. Methods: The levels of serum IL-2R in 30 patients with cervical cancer before and after interventional therapy were detected by ELISA, and compared with the normal control group. Results: The serum level of sIL - 2R in patients with cervical cancer before interventional therapy was significantly higher than that in the normal controls (P <0.01), and the level of sIL - 2R was positively correlated with the size of the lesions and clinical stage. Serum s The level of IL-2R was significantly lower than that before treatment (P <0.001), but still higher than that of the control group (P <0.05). CONCLUSIONS: The changes of serum sIL-2R in patients with cervical cancer are positively correlated with the clinical stage and the size and growth of the cancer. Detecting serum sIL-2R level before and after interventional therapy may be helpful to the judgment of the disease and the curative effect