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目的观察我国首例父子间活体小肠部分移植术患者围手术期血清可溶性血小板/T细胞活化抗原1(sPTA1)水平与排斥反应的相关性。方法用夹心ELISA法测定血清sPTA1水平。结果 于术后第67d出现移植物排斥反应。从发生排斥反应前2周开始,sPTA1呈逐渐升高 趋势,于排斥反应前5 d已达60.49 ng/ml,前1 d达71.64 ng/ml。经加强免 疫抑制后,血清sPTA1水平于次日迅速下降。结论活 体部分小肠 移植患者移植物浸润的杀伤性T细胞的活化是一个渐进的过程,只有在活化到一定程度时( 本例达术前近2倍时),才出现肉眼和组织病理学可见的移植物急性排斥反应,且血清sPTA1的下降较组织学恢复迅速。
Objective To observe the correlation between perioperative serum soluble platelet / T cell activating antigen 1 (sPTA1) levels and rejection in the first case of partial transplants between father and son living in our country. Methods Serum sPTA1 levels were measured by sandwich ELISA. Results The graft rejection occurred on the 67th day after operation. From 2 weeks before rejection, sPTA1 increased gradually, reaching 60.49 ng / ml 5 days before rejection and 71.64 ng / ml on the previous day. After enhanced immunosuppression, serum sPTA1 levels decreased rapidly the next day. Conclusion The activation of allograft infiltrating T-cells in patients with small bowel transplantation in vivo is a progressive process. Only when the degree of activation reaches a certain extent (nearly 2 times before surgery in this case) is macroscopic and histopathological findings Graft acute rejection, and serum sPTA1 decline more rapidly than histology.