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组蛋白H2A和H2B泛素化由一系列酶类催化介导,在基因转录调控当中存在重要的作用。H2A泛素化及相关酶类可能主要通过调节RNA聚合酶Ⅱ的延伸参与基因转录抑制,H2B泛素化及相关酶类对基因转录调控既存在抑制作用又具有促进作用,而且其在肿瘤发生发展中具有重要的调节作用。
Histone H2A and H2B ubiquitination is catalyzed by a series of enzymes that play an important role in gene transcription regulation. H2A ubiquitination and related enzymes may be involved in gene transcription inhibition mainly by regulating the extension of RNA polymerase II. H2B ubiquitination and related enzymes have both inhibitory and promoting effects on gene transcription and regulation, and their roles in tumorigenesis Has an important regulatory role.