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下丘脑性闭经的最新假设是,外源性GnRH能刺激下丘胸闭经患者的垂体促性腺细胞。 下丘脑—垂体门循环研究困难,周围血中GnRH水平极低且不恒定。已证实下丘脑—垂体门循环的GnRH分泌波动和外周循环LH分泌波动一致,从而使间接研究GnRH波动性分泌成为可能。 AHF的LH分泌周期和正常妇女卵泡前期的相同,AHF的LH在24小时内平均血清值偏低,波动减少,不规则,曲线低平有的甚至消失。在某些情况下,其波动幅度增大,大多数作者认为LH分泌波动幅度升高是AHF患者处于睡眠期,亦有人认为并非所有AHF患者睡眠期的LH分泌波动周都增加。正常妇女则卵泡前期其分泌周期反而减
The hypothesis of hypothalamic amenorrhea is that exogenous GnRH can stimulate pituitary gonadal cells in patients with inferior colliculus amenorrhea. Hypothalamus - pituitary gland circulation difficult to study, peripheral blood GnRH level is very low and not constant. It has been confirmed that the hypothalamic-pituitary gland circulation GnRH secretion fluctuations and peripheral circulation LH secretion fluctuations consistent, so that indirectly study GnRH volatility secretion possible. AHF LH secretion cycle and normal women the same as the pre-follicle, AHF LH in the 24-hour average serum value is low, the fluctuation decreases, irregular, curve low or even disappear. In some cases, the fluctuation of LH secretion is increased. Most authors think that the increase of LH secretion is in the sleep stage of AHF patients. Some people think that not all AHF patients have an increase in the cycle of LH secretion during sleep. Normal women are the pre-follicular phase of its secretion but reduced