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目的 阐明空腹血清总胆汁酸 (TBA)测定在婴儿巨细胞病毒性肝炎诊治中的临床意义。方法 采用全自动酶法分析技术对 80例婴儿巨细胞病毒性肝炎和 2 0例健康婴儿进行空腹血清胆汁酸测定 ,同时对患儿进行其他肝功能相关项目的测定 ,数据用SPSS 1 0 0统计软件进行分析。结果 (1 )巨细胞病毒性肝炎患儿血清TBA浓度与正常对照组差异有显著性意义 (P <0 .0 1 ) ;(2 )巨细胞病毒性肝炎轻、中、重、特重 ,TBA差异有显著性意义 (P <0 .0 1 ) ,TBA是反映肝功能损害的敏感指标 ;(3)TBA是反映疗效的敏感指标 (P <0 .0 1 )。结论 TBA对婴儿巨细胞病毒性肝炎病情的判断及疗效评定 ,有重要的参考价值。
Objective To clarify the clinical significance of fasting serum total bile acid (TBA) in the diagnosis and treatment of infantile cytomegalovirus hepatitis. Methods 80 cases of infant cytomegalovirus hepatitis and 20 healthy infants were tested for fasting serum bile acid by the method of automatic enzymatic analysis. At the same time, other liver function-related items were measured in children. The data were analyzed by SPSS 100 Software analysis. Results (1) Serum TBA levels in children with cytomegalovirus were significantly different from those in normal controls (P <0.01); (2) Cytomegalovirus hepatitis was mild, moderate, severe and severe (P <0.01). TBA was a sensitive indicator of liver dysfunction. (3) TBA was a sensitive indicator of efficacy (P <0.01). Conclusion TBA on infant cytomegalovirus disease evaluation and efficacy evaluation, there is an important reference value.