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《中药通报》一九八三年第三期刊登了“复方苦参注射液升白作用研究简报”一文。有关样品制备部分,笔者有以下几点看法与作者商榷。该文指出:“取苦参、黄芪分别用70～75%的乙醇渗漉,渗漉液通过732型阳离子交换树脂,……”。笔者认为此法不太妥当。众所周知,阳离子树脂上的磺酸基团只能与离子型的生物碱结合而达到交换,非离子型的生物碱是不能进行交换的。应当指出,原植物中的生物碱并非全部呈生物碱盐的形式存在。因此,对于象苦参这类含生物碱的药材,由于其生物碱具有水溶性,可将其渗漉液进行酸化后再进行交换。或用稀酸溶液对药材进行渗漉,然后渗
In the third issue of the “Chinese Medicine Bulletin” in 1983, a paper “Study on the role of compound Kushen injection in promoting whitening” was published. Regarding the sample preparation section, the author has the following points of view to discuss with the author. The article states: “Put flavescens and astragalus, respectively, with 70-75% ethanol to percolate, the osmotic fluid passes through 732 cation exchange resin, ...”. The author thinks this method is not appropriate. It is known that sulfonic acid groups on the cationic resin can only be exchanged with ionic alkaloids, and non-ionic alkaloids cannot be exchanged. It should be noted that not all alkaloids in the original plant exist in the form of alkaloid salts. Therefore, for alkaloid-containing medicinal materials such as Sophora flavescens, since the alkaloids are water-soluble, their percolation liquids can be acidified and then exchanged. Or use dilute acid solution to permeate the medicinal materials, then seep