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目的:探讨肿瘤坏死因子(TNF)和可溶性白细胞介素2受体(sIL-2R)在格林-巴利综合征(GBS)发病中的作用及其临床意义。方法:采用双抗体夹心ELISA法对28例GBS患者和36例正常对照血清TNF及sIL-2R水平进行了检测。结果:GBS组血清TNF及sIL-2R水平显著高于正常对照组,血清TNF及sIL-2R水平变化与GBS病情及预后密切相关,恢复期血清TNF及sIL-2R水平显著降低。结论:TNF及sIL-2R参与了GBS的发病过程,检测血清TNF及sIL-2R水平对判定GBS病情及预后有一定的临床意义。
Objective: To investigate the role of tumor necrosis factor (TNF) and soluble interleukin 2 receptor (sIL-2R) in the pathogenesis of Guillain-Barre syndrome (GBS) and its clinical significance. Methods: Serum levels of TNF and sIL-2R in 28 GBS patients and 36 normal controls were detected by double antibody sandwich ELISA. Results: Serum levels of TNF and sIL-2R in GBS group were significantly higher than those in normal control group. The changes of serum TNF and sIL-2R levels were closely related to the severity and prognosis of GBS. The level of TNF and sIL-2R in convalescent serum was significantly decreased. CONCLUSIONS: TNF and sIL-2R are involved in the pathogenesis of GBS. The detection of serum TNF and sIL-2R levels has some clinical significance in judging the condition and prognosis of GBS.