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目的:探讨胃苏颗粒联合西药治疗老年胃食管反流病(GERD)的临床疗效。方法:回顾性分析2015年3月~2016年10月在厦门大学附属第一医院杏林分院接受治疗的GERD老年患者的临床资料。根据其治疗方式分为对照组和观察组,其中对照组给予常规西药治疗,观察组给予胃苏颗粒联合西药治疗。治疗4周后,观察两组患者的治疗效果,比较两组患者治疗前后反流检查计分(RFS)、压痛程度、炎症细胞因子水平、临床症状体征改善情况和不良反应发生率的差异。结果:治疗后观察组总有效率显著高于对照组,RFS、VAS评分及血清IL-18、IL-6、hsCRP水平显著低于对照组,反酸、烧心和腹痛等积分显著低于对照组(P<0.05)。两组患者腹泻、肝肾功能受损等不良反应发生率差异无统计学意义。结论:胃苏颗粒联合西药对老年GERD患者有良好的疗效,可缓解症状,降低血清炎症细胞因子水平。
Objective: To investigate the clinical efficacy of Weisu granule combined with western medicine in the treatment of senile gastroesophageal reflux disease (GERD). Methods: The clinical data of elderly patients with GERD treated in Xinglin Branch of First Affiliated Hospital of Xiamen University from March 2015 to October 2016 were retrospectively analyzed. According to the way of treatment, they were divided into control group and observation group. The control group was given conventional western medicine, and the observation group was given Weiweisi Granules combined with western medicine. After 4 weeks of treatment, the therapeutic effects of the two groups were observed. The difference of reflux score (RFS), tenderness, inflammatory cytokines, clinical signs and symptoms and the incidence of adverse reactions were compared between the two groups before and after treatment. Results: After treatment, the total effective rate of the observation group was significantly higher than that of the control group. The scores of RFS, VAS, serum IL-18, IL-6 and hsCRP were significantly lower than those of the control group. The scores of acid reflux, heartburn and abdominal pain were significantly lower than those of the control group (P <0.05). Two groups of patients with diarrhea, liver and kidney dysfunction and other adverse reactions no significant difference in the incidence. Conclusion: Weizhu granule combined with western medicine has a good curative effect on elderly patients with GERD, which can relieve symptoms and reduce serum levels of inflammatory cytokines.