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目的探讨胰腺腺鳞癌的影像、病理及肿瘤生物学行为的特点,以期提高对本病的认识,进而尽早做出正确诊断,制定恰当、合理治疗措施,改善患者的预后。资料与方法回顾性分析、总结经病理证实的3例胰腺腺鳞癌患者的影像学资料、相关实验室检查、治疗方法及预后。结果1例表现为中央明显坏死、液化的胰头肿瘤,另2例表现呈浸润性生长、早期出现转移。镜下肿瘤呈现腺癌和鳞癌的形态特点,免疫组织化学提示肿瘤含有腺癌和鳞癌成分。术后患者生存3～11个月,均死于肿瘤复发和肝转移。结论肿瘤中央出现明显坏死、液化,或呈浸润性生长、早期出现转移是胰腺腺鳞癌的特点。
Objective To explore the imaging, pathology and biological characteristics of pancreatic adenosquamous carcinoma in order to improve the understanding of this disease and to make the correct diagnosis as soon as possible and to formulate appropriate and reasonable treatment measures to improve the prognosis of patients. Materials and Methods Retrospective analysis of three cases of pancreatic adenosquamous carcinoma confirmed by pathology, imaging data, related laboratory tests, treatment methods and prognosis. Results One case showed obvious central necrosis and liquefied pancreatic head tumor. The other two cases showed infiltrative growth and early metastasis. Microscopic appearance of adenocarcinoma and squamous cell carcinoma morphological features, immunohistochemistry prompted the tumor contains adenocarcinoma and squamous cell carcinoma components. Postoperative patients survived 3 to 11 months, both died of tumor recurrence and liver metastases. Conclusion The tumor showed obvious necrosis, liquefaction or infiltrative growth. Early metastasis is characteristic of pancreatic adenosquamous carcinoma.