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201058 全反式维甲酸和1,25-二羟维生素D_3联合应用对大肠癌细胞的分化诱导作用/郭俊明…//癌症.-1999,18(6).-649～651 以MTT法测定细胞生长,ALP比活性检测细胞分化。结果:ATRA和1,25-二羟维生素D_3对LoVo生长的抑制作用在一定范围内呈时间浓度依赖关系,联合用药时抑制作用增强。经药物作用细胞后肠型ALP逐渐升高。认为联合使用ATRA和1,25-二羟维生京D_3诱导LoVo细胞分化比
201058 The combination of all-trans retinoic acid and 1,25-dihydroxyvitamin D_3 induces the differentiation of colorectal cancer cells Guo Junming...//Cancer.-1999,18(6).-649-651 Cell Measured by MTT Growth, ALP activity was measured by cell differentiation. Results: The inhibitory effect of ATRA and 1,25-dihydroxyvitamin D 3 on the growth of LoVo was time-and concentration-dependent within a certain range, and the inhibitory effect was enhanced when the drugs were combined. After the cells were treated with drugs, the intestinal ALP gradually increased. It is thought that the combination of ATRA and 1,25-dihydroxyvitamin D3 can induce LoVo cell differentiation