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目的 :探讨尿纤维结合蛋白 (Fn)水平变化在狼疮肾炎中的临床意义。方法 :采用ELISA法对 1 8例狼疮肾炎患者和 1 0例正常对照组进行尿Fn水平检测 ,比较分析其相互之间的差异及与系统性红斑狼疮 (SLE)活动指数 (SLEDAI)的相关关系。结果 :狼疮肾炎患者尿Fn水平活动期为 732 .73± 32 6 .51ng/ml,静止期为1 1 6 .0 7± 52 .1 0ng/ml,明显高于正常对照组 1 9.86± 7.1 9ng/ml(P <0 .0 5) ,并且活动期高于静止期 (P <0 .0 0 1 ) ,尿Fn水平与SLEDAI呈正相关 (r =0 .934 ,P <0 .0 5)。结论 :尿Fn水平可作为狼疮肾炎患者活动度的敏感指标之一。
Objective: To investigate the clinical significance of urinary fibronectin (Fn) level changes in lupus nephritis. Methods: Urine Fn levels were detected by ELISA in 18 patients with lupus nephritis and 10 normal controls. The differences between them and their correlation with SLE index (SLEDAI) were analyzed. . Results: The activity of urinary Fn in patients with lupus nephritis was 732.73 ± 32.6.51ng / ml and the resting time was 116.60.7 ± 52.0ng / ml, which was significantly higher than that of the normal control group 1 9.86 ± 7.19ng / ml (P <0.05), and the activity was higher than that of quiescent (P <0.01). The urinary Fn level was positively correlated with SLEDAI (r = 0.944, P <0.05). Conclusion: The urinary Fn level can be used as one of the sensitive indexes of activity in patients with lupus nephritis.