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目的观察白细胞单采联合化疗对高白细胞急性白血病的治疗效果。方法通过细胞单采联合化疗治疗50名高白细胞急性白血病患者与13名单一化疗组患者疗效对比,评估细胞单采联合化疗治疗对高白细胞急性白血病的临床应用效果。结果 50名高白细胞急性白血病患者经白细胞单采后化疗,缓解率达68%,早期死亡率4%。单一化疗组13例化疗后3周内死亡3例,早期死亡率达38.4%。结论细胞单采联合化疗治疗高白细胞急性白血病可显著提高近期疗效,是有效、安全的,但对远期生存率尚未发现有明显改善。
Objective To observe the therapeutic effect of leukocyte apheresis combined chemotherapy on high leukemia acute leukemia. Methods 50 patients with acute leukemia treated by single-cell combined with chemotherapy were compared with those of 13 single-chemotherapy groups to evaluate the clinical effect of single-cell combined chemotherapy on patients with acute leukemia. Results Fifty patients with acute leukemia of leukemia were treated with leukocyte single post-chemotherapy, the response rate was 68% and the early mortality rate was 4%. In the single chemotherapy group, 13 patients died within 3 weeks after chemotherapy and the early mortality rate reached 38.4%. Conclusions The combination of chemotherapy and single-cell chemotherapy in the treatment of acute leukemia patients with acute leukemia can significantly improve the short-term efficacy, which is effective and safe. However, no significant improvement has been found in the long-term survival rate.