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目的研究兰索拉唑与莫沙必利联合治疗反流性食管炎的临床疗效。方法 128例反流性食管炎患者随机分为治疗组和对照组各64例。治疗组采用兰索拉唑与莫沙必利联合治疗,对照组兰索拉唑治疗。观察治疗前后两组临床症状积分、临床疗效和内镜下疗效变化及不良反应发生情况。结果治疗组症状积分降低较对照组明显,临床总有效率亦明显优于对照组,内镜下食管粘膜炎症得到有效控制,与对照组相比,差异均具有显著性(P<0.05)。两组均未见严重不良反应。结论兰索拉唑联合莫沙必利治疗反流性食管炎临床疗效确切,可在临床上推广应用。
Objective To study the clinical efficacy of lansoprazole and mosapride in the treatment of reflux esophagitis. Methods 128 cases of reflux esophagitis patients were randomly divided into treatment group and control group of 64 cases. The treatment group treated with lansoprazole and mosapride, the control group lansoprazole treatment. Before and after treatment, the clinical symptom score, clinical efficacy, endoscopic efficacy and adverse reactions were observed. Results The symptom score of the treatment group was significantly lower than that of the control group, and the total clinical effective rate was also significantly better than that of the control group. Endoscopic esophageal mucosal inflammation was effectively controlled. The difference was significant compared with the control group (P <0.05). No serious adverse reactions were seen in both groups. Conclusions Lansoprazole combined with mosapride in the treatment of reflux esophagitis clinical curative effect can be clinically applied.