论文部分内容阅读
目的:筛查多囊卵巢综合征(PCOS)合并不孕患者自体免疫性甲状腺疾病(AITD)的发病情况。方法:对492例PCOS合并不孕患者为研究组,另631例其他不孕症患者为对照组,应用化学发光法进行血清促甲状腺激素(TSH)和抗甲状腺免疫球蛋白抗体(TGAb)及抗甲状腺过氧化物酶抗体(TPOAb)检测,并对两组进行甲状腺大小观诊和触诊检查。结果:研究组患者TGAb为(68.95±168.23)U/ml,TPOAb为(112.31±162.13)U/ml,对照组为(38.73±181.68)U/ml和(43.12±189.38)U/ml,差异有统计学意义(P<0.01);TGAb及TPOAb阳性率研究组(69.51%和35.34%)亦明显高于对照组(61.82%/25.03%),差异有统计学意义(P<0.05);TSH在两组中差异无统计学意义(P>0.05)。研究组甲状腺1、2、3级肿大分别为139、95、39例,对照组为49、31、9例,差异有统计学意义(P<0.05)。结论:PCOS合并不孕患者中AITD有高的发病率,PCOS合并不孕患者应进行AITD的筛查诊治,以提高助孕成功率。
Objective: To screen the incidence of autoimmune thyroid disease (AITD) in patients with polycystic ovary syndrome (PCOS) and infertility. Methods: A total of 492 PCOS patients with infertility were enrolled as study group, and 631 other infertile patients as control group. Serum thyroid stimulating hormone (TSH), anti-thyroglobulin antibody (TGAb) and anti-thyroglobulin antibody Thyroid peroxidase antibody (TPOAb) detection, and the two groups of thyroid size and palpation examination. Results: The TGAb of the study group was (68.95 ± 168.23) U / ml, the TPOAb was (112.31 ± 162.13) U / ml and the control group was (38.73 ± 181.68) U / ml and (43.12 ± 189.38) U / (P <0.01). The positive rates of TGAb and TPOAb in the study group (69.51% and 35.34%) were also significantly higher than those in the control group (61.82% / 25.03%), with statistical significance (P <0.05) There was no significant difference between the two groups (P> 0.05). Thyroid grade 1, 2 and 3 in the study group were 139, 95 and 39 cases, respectively. The control group was 49, 31 and 9 cases, with significant difference (P <0.05). Conclusion: AITD in PCOS patients with infertility has a high incidence, and PCOS patients with infertility should be screened for AITD to improve the success rate of pregnancy-assisted pregnancy.