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目的 探讨银杏叶制剂 (GBE)对蛛网膜下腔出血 (SAH )后神经功能的保护作用。方法 对假手术对照组 ,SAH模型组和GBE处理组大鼠检测 2 4h内局部脑血流量 (rCBF)、体感诱发电位 (SEP)和脑组织一氧化氮 (NO )含量的动态变化。结果 SAH后rCBF持续下降 ,SEP潜伏期逐渐延长 ,脑组织NO含量显著增加。GBE有效拮抗上述指标的变化。结论 GBE能缓解SAH所致神经功能损伤 ,其机制之一为逆转脑组织NO的异常改变。
Objective To investigate the protective effect of Ginkgo biloba extract (GBE) on neurological function after subarachnoid hemorrhage (SAH). Methods The dynamic changes of regional cerebral blood flow (rCBF), somatosensory evoked potential (SEP) and brain tissue nitric oxide (NO) levels in sham operation control group, SAH model group and GBE treatment group were detected within 24 hours. Results rCBF continued to decline after SAH, SEP latency gradually extended, NO content in brain tissue increased significantly. GBE effectively antagonize the above indicators of change. Conclusion GBE can alleviate the neurological damage induced by SAH, one of the mechanisms is to reverse the abnormal changes of NO in brain tissue.