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目的 :研究唐山大地震所致慢性创伤后应激障碍患者基础血清皮质醇浓度和地塞米松抑制试验。方法 :唐山大地震所致创伤后应激障碍 3 5例 (研究组 )和 3 3例正常人 (对照组 )接受了基础血清皮质醇水平的测定和地塞米松抑制试验。结果 :两组基础血清皮质醇水平比较差异无统计学显著性 ,各组男女之间基础血清皮质醇水平分别比较差异亦无统计学显著性。两组服用相同剂量的地塞米松后 ,研究组血清皮质醇水平低于对照组和对血清皮质醇的抑制作用高于对照组 ,差异均有统计学显著性。各组男女之间的基础血清皮质醇水平、服用地塞米松后血清皮质醇水平和对地塞米松的抑制率比较差异无统计学显著性。结论 :唐山大地震所致慢性PTSD患者对糖皮质激素的敏感性增高而导致PHA轴负反馈抑制增强 ,无性别差异
Objective: To study the basal serum cortisol concentration and dexamethasone inhibition in patients with chronic posttraumatic stress disorder caused by the Tangshan earthquake. Methods: Thirty five patients (study group) and 33 normal controls (control group) suffered from Tangshan earthquake-induced post-traumatic stress disorder received baseline serum cortisol level measurement and dexamethasone suppression test. Results: There was no significant difference in basal serum cortisol levels between the two groups. There was no significant difference in baseline serum cortisol levels between men and women in each group. Two groups taking the same dose of dexamethasone, the study group serum cortisol levels lower than the control group and the serum cortisol inhibition higher than the control group, the differences were statistically significant. The baseline serum cortisol level between men and women in each group, serum cortisol level after taking dexamethasone and the inhibition rate to dexamethasone were not statistically significant. Conclusion: The sensitivity to glucocorticoid in patients with chronic PTSD caused by the Tangshan earthquake is increased, which leads to the negative feedback inhibition of PHA axis increasing without gender difference