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目的 :探讨 SAPO- 1/ Fas在急性白血病患者血浆浓度的变化及与化疗效果的相关性。方法 :用双抗体夹心 EL ISA法对 92例初诊的急性白血病进行血浆 SAPO- 1/ Fas浓度测定 ,并对其中 6 8例进行了化疗中、化疗后动态观察 ,同时设健康对照组。结果 :急性白血病患者血浆 SAPO- 1/Fas较正常对照组明显升高 (P<0 .0 1) ,化疗缓解者化疗中、化疗后 SAPO- 1/ Fas显著下降 ,而化疗未缓解者化疗中、化疗后 SAPO- 1/ Fas水平仍明显高于正常对照组 (P<0 .0 1)。结论 :血浆 SAPO- 1/ Fas浓度与急性白血病患者及其治疗效果有明显相关性
Objective: To investigate the change of plasma concentration of SAPO-1 / Fas in patients with acute leukemia and its correlation with chemotherapy efficacy. Methods: The plasma concentration of SAPO-1 / Fas in 92 cases of newly diagnosed acute leukemia was determined by double antibody sandwich ELISA method, and 68 of them were observed after chemotherapy and after chemotherapy, and the healthy control group was also established. Results: The level of SAPO-1 / Fas in plasma of patients with acute leukemia was significantly higher than that of the normal control group (P <0.01). In chemotherapy, the level of SAPO-1 / Fas decreased significantly after chemotherapy, The level of SAPO-1 / Fas after chemotherapy was still significantly higher than that of the normal control group (P <0.01). Conclusion: There is a significant correlation between plasma SAPO-1 / Fas concentration and acute leukemia patients and their therapeutic effect