论文部分内容阅读
目的:探讨痰热清注射液对卡介苗致敏脂多糖攻击诱导小鼠急性肝损伤的影响。方法:采用卡介苗致敏脂多糖攻击诱导小鼠免疫性肝损伤,检测小鼠血清ALT,AST活性和TBIL含量,测定肝脏指数,HE染色观察肝组织病理变化。结果:痰热清注射液各剂量组均可明显降低ALT,AST活性;高、中剂量组均可明显降低肝脏指数;各剂量组能明显改善肝细胞组织坏死损伤。结论:痰热清注射液对卡介苗致敏脂多糖攻击小鼠免疫性肝损伤具有保护作用。
Objective: To investigate the effect of Tanreqing injection on acute hepatic injury induced by BCG-induced lipopolysaccharide in mice. Methods: Immunological liver injury induced by BCG-induced lipopolysaccharide was detected in mice. Serum ALT, AST and TBIL levels were measured. The liver index was measured. The pathological changes of liver were observed by HE staining. Results: Tanreqing injection of each dose group can significantly reduce the ALT, AST activity; high and medium dose groups were significantly lower liver index; each dose group can significantly improve liver tissue necrosis. CONCLUSION: Tanreqing injection has a protective effect on immune-induced liver injury induced by BCG-induced lipopolysaccharide in mice.