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药物是防病治病的主要手段。药物作用的结果,不仅取决于药物本身的性质,且与病人的机能状态密切相关。儿童是正处于迅速生长发育中的机体,具有独特的病理生理特点,因而对药物也具有特殊的反应性。本文根据儿童的病理生理等特点,从多药联用、重复用药、剂量折算、用药依从性及药动学和药效学等方面对儿童用药安全性进行探讨,对儿童合理、安全用药具有指导意义。
Drugs are the main means of preventing and curing diseases. The result of drug action depends not only on the nature of the drug itself, but also on the patient’s functional status. Children are in the rapid growth and development of the body, has a unique pathophysiological characteristics, and therefore also has a special drug reactivity. Based on the characteristics of children’s pathophysiology, this article explores the drug safety of children from the aspects of multi-drug combination, repeated drug use, dose conversion, drug compliance and pharmacokinetics and pharmacodynamics, etc., and provides guidance to children’s rational and safe drug use. significance.