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目的:观察口服小剂量阿司匹林对孕妇妊娠期血液高凝的临床改善。方法:选取2015年1月至2016年6月于佛山市三水区人民医院门诊孕检的孕妇4000例抽查凝血四项,D–二聚体(D–D),把D–D高于1650 IU·m L~(-1)的400例孕妇进入研究范围,400例孕妇平均年龄27岁,平均孕周28周,出现并发症的记录后退出研究范围,400例孕妇随机分为:A组200例为观察组,口服阿司匹林,B组100例,给予安慰剂及C组100例,未给任何处理;观察母婴妊娠结局:妊娠并发症:产后出血、子痫前期、胎盘早剥、栓塞性疾病、围产儿情况:胎儿生长受限、新生儿窒息。结果:观察组妊娠期高血压疾病发生率、胎儿生长受限、胎盘早剥、栓塞性疾病、新生儿窒息率均低于对照组,差异有统计学意义(P<0.05),三组孕妇产后出血率比较,差异无统计学意义(P>0.05);对照组B,对照组C妊娠结局与并发症比较,差异无统计学意义(P>0.05)。结论:小剂量阿司匹林能够有效改善妊娠期血液高凝状态,并改善最终的妊娠结局。
Objective: To observe the clinical improvement of low blood dose aspirin in pregnant women during pregnancy. Methods: From January 2015 to June 2016, 4000 pregnant women of pregnant women in outpatient pregnancy examination in Sanshui District People’s Hospital of Foshan City were included in the study. Four blood samples of D-D and D-D were tested. The D-D was higher than 1650 400 pregnant women of IU · m L -1 entered the study range. The mean age of 400 pregnant women was 27 years old and the average gestational age was 28 weeks. After the complication was recorded, the patients were withdrawn from the study range. 400 pregnant women were randomly divided into A group 200 cases as observation group, aspirin orally, 100 cases in group B, 100 cases in placebo group and 100 cases in group C without any treatment. Observation of maternal and fetal pregnancy outcome: pregnancy complications: postpartum hemorrhage, preeclampsia, placental abruption, embolism Sexually transmitted diseases, perinatal conditions: Fetal growth restriction, neonatal asphyxia. Results: The incidence of pregnancy-induced hypertension, fetal growth restriction, placental abruption, embolic disease and neonatal asphyxia in observation group were significantly lower than those in control group (P <0.05) There was no significant difference in bleeding rate between the two groups (P> 0.05). There was no significant difference in pregnancy outcome and complication between control group B and control group C (P> 0.05). Conclusions: Low-dose aspirin can effectively improve blood hypercoagulability in pregnancy and improve the final pregnancy outcome.