论文部分内容阅读
目的 建立脑动静脉畸形 (AVM)模型 ,检测其血流动力学改变。方法 将大鼠左侧颈外静脉与颈总动脉行端侧吻合 ,测定吻合前后及模型动物饲养 16周后的血流动力学改变。结果 大鼠静脉动脉的端侧吻合形成动静脉分流 ,左侧局部脑血流量显著降低、右侧颈外静脉压增加、颈总动脉压降低 ,血流速度增快。16周后左侧局部脑血流量较动静脉吻合形成即刻升高、右侧颈外静脉压和颈总动脉血流速度进一步增加 ,右侧颈总动脉压无明显改变。结论 大鼠颈部动静脉分流形成低灌注压、高血流量、静脉高压的模型 ,符合 AVM的血流动力学特征。长期的脑低灌注压使脑血管反应改变 ,脑血流量有所增加
Objective To establish a model of cerebral arteriovenous malformation (AVM) and measure its hemodynamic changes. Methods The left external jugular vein and common carotid artery were anastomosed to the left and the right hemodynamic changes were measured before and after anastomosis and the model animals were fed for 16 weeks. Results Arteriovenous shunt was formed by anastomosis of venous artery in rats. The left partial cerebral blood flow decreased significantly. The right external jugular venous pressure was increased. The common carotid artery pressure was decreased and blood flow velocity was increased. After 16 weeks, the left partial cerebral blood flow immediately anastomosed to the arteriovenous anastomosis, the right external jugular venous pressure and common carotid artery blood flow velocity increased further, and the right common carotid artery pressure did not change significantly. Conclusion The shunting of the arteries and veins in the neck of rats results in a model of hypoperfusion, high blood flow and venous hypertension, which is in accordance with the hemodynamics of AVM. Long-term cerebral hypoperfusion pressure changes of cerebrovascular response, cerebral blood flow has increased