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以天然产物Aspernigerin为先导,将Aspernigerin结构中的一个1,2,3,4-四氢喹啉基团以芳胺类化合物替代,设计合成了15个未见文献报道的Aspernigerin类似物,结构均经过1H NMR,IR和元素分析确证.初步生物活性测试表明,大部分目标化合物均表现出了一定的杀虫和杀菌活性,其中化合物2n在200μg/mL的浓度下对小菜蛾仍表现出100%的杀虫活性,优于先导Aspernigerin和对照药剂噻虫嗪;化合物2d,2e,2j,2k表现出对黄瓜灰霉病优于先导Aspernigerin的抑制活性.
Aspernigerin, a natural product, was used to replace a 1,2,3,4-tetrahydroquinoline group in Aspernigerin with aromatic amines. Fifteen unknown analogs of Aspernigerin were designed and synthesized The results of 1H NMR, IR and elemental analysis confirmed that the preliminary bioassay showed that most of the target compounds showed certain insecticidal and bactericidal activities, and compound 2n still showed 100% inhibition against Plutella xylostella at a concentration of 200 μg / mL Insecticidal activity superior to lead Aspernigerin and the control agent thiamethoxam and compounds 2d, 2e, 2j, 2k showed superior inhibitory activity against Aspernigerin in cucumber gray mold disease.