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一、前言神经组织含有大量磷脂,它们参与神经组织的构成,还具有与神经功能密切相关的生物活性,当磷脂代谢发生障碍时,脑和脊髓的功能便会发生紊乱而出现各种疾患。Konberg(1953年),Kennedy(1957年)的研究阐明,胞二磷胆碱(以下简称CDP-胆碱)是磷脂代谢的重要前体,是卵磷脂生物合成必需的辅酶。早日修(1961年)从生物化学的角度出发,对动物进行脑外伤实验,发现当动物发生脑外伤时,脑组织
I. INTRODUCTION Nerve tissue contains a large amount of phospholipids, which are involved in the formation of nerve tissue. They also have biological activity closely related to nerve function. When the phospholipid metabolism is impaired, the brain and spinal cord functions disorderly and various diseases occur. Studies by Konberg (1953) and Kennedy (1957) have shown that citicoline (CDP-choline), an important precursor for phospholipid metabolism, is a coenzyme necessary for lecithin biosynthesis. Early repair (1961) From the biochemical point of view, the animals were traumatic brain injury experiments found that when the animal brain trauma, the brain tissue