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目的 探讨在进展期胃癌根治术中一次性腹腔低渗化疗的治疗作用。方法 对术中行一次性腹腔低渗化疗的 3 0例进展期胃癌患者 ,与未行此方法治疗 18例患者的腹腔游离癌细胞检出率及生存率和死亡原因进行对比研究。结果 治疗组冲洗液中癌细胞的检出率为 6.7%。对照组为 3 3 .3 % (P <0 .0 1)。治疗组 3、5年生存率分别为 63 .3 %、46.7%。对照组为 3 8.9%、16.7%(P <0 .0 1)。结论 一次性腹腔低渗化疗具有杀灭腹腔游离癌细胞的作用 ,可改善进展期胃癌的预后。
Objective To investigate the therapeutic effect of one-off intraperitoneal hypotonic chemotherapy in radical gastrectomy of advanced gastric cancer. Methods 30 cases of patients with advanced gastric cancer undergoing peritoneal hypotonic chemotherapy were compared with those of 18 cases without peritoneal cavity cancer and the survival rate and cause of death were compared. Results The detection rate of cancer cells in the treatment group was 6.7%. The control group was 33.3% (P <0.01). The 3-year and 5-year survival rates of the treatment group were 63.3% and 46.7%, respectively. The control group was 8.9%, 16.7% (P <0.01). Conclusions One-off intraperitoneal hypotonic chemotherapy has the effect of killing peritoneal free cancer cells and can improve the prognosis of advanced gastric cancer.