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利用细胞因子诱生及ＥＬＩＳＡ等技术，研究了３８例不同分期的鼻咽癌（ＮＰＣ）患者、２３例正常人外周血单个核细胞（ＰＢＭＣ）分泌的细胞因子模式，较系统地研究了ＣＤ４＋Ｔ淋巴细胞亚群Ｔｈ１和Ｔｈ２所分泌的代表性的细胞因子类型ＩＬ－２、ＩＦＮ－γ、ＩＬ－４、ＩＬ－６、ＩＬ－１０等的变化；同时检测了ＮＰＣ患者血清中ＩＬ－２和ＩＬ－４水平。发现ＮＰＣ患者ＰＢＭＣ体外分泌ＩＬ－２的水平下降，ＩＬ－４的水平增高；血清中ＩＬ－２水平降低，而ＩＬ－４的水平显著升高，并且随着病程有进行性发展的趋势。提示Ｔｈ１／Ｔｈ２细胞亚群在不同临床分期的ＮＰＣ患者呈现比例失调，且随着病程的发展Ｔｈ１细胞亚群的减少更加明显
The cytokine patterns of peripheral blood mononuclear cells (PBMCs) secreted by 38 NPC patients with NPC (NPC) and 23 normal controls (PBMCs) were studied by cytokine induction, ELISA and other techniques. The effects of CD4 + T lymphocyte The changes of IL-2, IFN-γ, IL-4, IL-6, IL-10 and other cytokines secreted by Th1 and Th2 cell subsets were detected. The levels of IL-2 and IL -4 level. The levels of IL-2 secreted by PBMCs in NPC patients were significantly lower than those in NPC patients, while IL-4 levels were elevated in serum. The level of IL-2 in serum was decreased, but the level of IL-4 was significantly increased. It is suggested that the proportion of Th1 / Th2 subpopulations in patients with NPC with different clinical stages is imbalanced, and the decrease of Th1 subpopulation is more obvious as the course of disease progresses