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眼球突出骨发育障碍病为传染性网状内皮细胞新陈代谢障碍所致,1893年Hand首先报告一例两侧眼球突出,男孩,有烦渴及尿崩症史,尸检发现肝、脾有类脂质增多。1915年Schuller报告两例,并从放射学观点对颅骨病变详细讨论。1919年Christian报
Obstructive osteogenesis imperfecta is caused by the metabolic disorder of infectious reticuloendothelial cells. In 1893 Hand first reported a case of bilateral prominent ocular protrusions. Boys had a history of polydipsia and diabetes insipidus. Autopsy revealed increased lipids in the liver and spleen. . In 1915 Schuller reported two cases and detailed discussions of skull lesions from a radiological point of view. The 1919 Christian Report